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Abstral Sublingual 100MG

Highlights:

Abstral Sublingual 100MG  tablets should be administered directly under the tongue at the deepest part. Abstral sublingual tablets should not be swallowed, but allowed to completely dissolve in the sublingual cavity without chewing or sucking. Patients should be advised not to eat or drink anything until the sublingual.

Abstral Sublingual 100MG

Highlights:

Abstral Sublingual 100MG

Abstral Sublingual 100MG , 200 microgram, 300 microgram, 400 microgram, 600 microgram, 800 microgram sublingual tablets

2. Qualitative and quantitative composition

Each sublingual tablet contains:

100 micrograms fentanyl (as citrate)

200 micrograms fentanyl (as citrate)

300 micrograms fentanyl (as citrate)

400 micrograms fentanyl (as citrate)

600 micrograms fentanyl (as citrate)

800 micrograms fentanyl (as citrate)

For the full list of excipients, see section 6.1.

3. Pharmaceutical form

Sublingual tablet

100 microgram sublingual tablet is a white round tablet

200 microgram sublingual tablet is a white oval-shaped tablet

300 microgram sublingual tablet is a white triangle-shaped tablet

400 microgram sublingual tablet is a white diamond-shaped tablet

600 microgram sublingual tablet is a white “D”-shaped tablet

800 microgram sublingual tablet is a white capsule-shaped tablet

4. Clinical particulars
4.1 Therapeutic indications

Management of breakthrough pain in adult patients using opioid therapy for chronic cancer pain. Breakthrough pain is a transient exacerbation of otherwise controlled chronic background pain.

4.2 Posology and method of administration

Abstral Sublingual 100MG,   should only be administered to patients who are considered tolerant to their opioid therapy for persistent cancer pain. Patients can be considered opioid tolerant if they take at least 60 mg of oral morphine daily, at least 25 micrograms of transdermal fentanyl per hour, at least 30 mg of oxycodone daily, at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid for a week or longer.

Method of administration:

Abstral Sublingual 100MG  tablets should be administered directly under the tongue at the deepest part. Abstral sublingual tablets should not be swallowed, but allowed to completely dissolve in the sublingual cavity without chewing or sucking. Patients should be advised not to eat or drink anything until the sublingual tablet is completely dissolved.

In patients who have a dry mouth water may be used to moisten the buccal mucosa before taking Abstral.

Dose titration:

The object of dose titration is to identify an optimal maintenance dose for ongoing treatment of breakthrough pain episodes. This optimal dose should provide adequate analgesia with an acceptable level of adverse reactions.

The optimal dose of Abstral will be determined by upward titration, on an individual patient basis. Several doses are available for use during the dose titration phase. The initial dose of Abstral used should be 100 micrograms, titrating upwards as necessary through the range of available dosage strengths.

Patients should be carefully monitored until an optimal dose is reached.

Switching from other fentanyl containing products to Abstral must not occur at a 1:1 ratio because of different absorption profiles. If patients are switched from another fentanyl containing product, a new dose titration with Abstral is required.

The following dose regimen is recommended for titration, although in all cases the physician should take into account the clinical need of the patient, age and concomitant illness.

All patients must start therapy with a single 100 microgram sublingual tablet. If adequate analgesia is not obtained within 15-30 minutes of administration of a single sublingual tablet, a supplemental (second) 100 microgram sublingual tablet may be administered. If adequate analgesia is not obtained within 15-30 minutes of the first dose an increase in dose to the next highest tablet strength should be considered for the next episode of breakthrough pain (Refer to figure below).

Dose escalation should continue in a stepwise manner until adequate analgesia with tolerable adverse reactions is achieved. The dose strength for the supplemental (second) sublingual tablet should be increased from 100 to 200 micrograms at doses of 400 micrograms and higher. This is illustrated in the schedule below. No more than two (2) doses should be administered for a single episode of breakthrough pain during this titration phase.

 

ADB-F

Highlights:

5F-ADB (also known as 5F-MDMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug.[1] 5F-ADB is a potent agonist of the CB1 receptor,[2] though it is unclear whether it is selective for this target. 5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance. Subsequent testing identified 5F-ADB to have been present in a total of ten people who had died from unexplained drug overdoses in Japan between September 2014 and December 2014. 5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples, and appears to be significantly more toxic than earlier synthetic cannabinoid drugs that had previously been sold.

Adderall 30 MG

Highlights:

Adderall 30 MG

Adderall 30 MG is a kind of drug which is formed by combining and dextroamphetamine. These two components serve as primary stimulants of a nervous system. Plus, these stimulants impact on brain chemicals and nerves to control impulse and hyperactivity. The drug is basically used to cure narcolepsy and hyperactivity disorder (ADHD). It is allowed to consume in specific countries, predominately Canada and United States.

Precautions Regarding Dosage:

There could be need of taking Adderall XR in a person but one must consult to doctor before the first dose if he/she have overactive thyroid, moderate to severe high blood pressure, glaucoma, any heart disease or even if a person was drug or alcohol addict previously. People are also advised to not to abuse its dosage as it might cause serious side effects on the heart or even worse, death.

Positive Outcome:

As consuming drugs of any sort have effects whether negative or positive. Adderall 30 MG has as well. This has been observed that using it for shorter span as directed by physician, impacts on person’s health positively due to prevention of ADHD symptoms. It happens because:

  • It increases presence of neurotransmitters in our brains such as dopamine and norepinephrine. Also, these specific chemicals in brain function as to boost energy levels, alertness and attention as well.
  • The drug can increase heart rate and maintains flow of blood to the muscles.
  • Constant use of it as per doctors advised can generate higher energy and invigoration which is said to be similar to the cocaine consumption.

Negative Outcome:

Since it is one of the sensitive drugs and consuming Adderall 30 MG even after expert’s prescription might impact negatively on health.

  • Irritability
  • Unhealthy weight loss due to appetite suppression
  • Restlessness and disturbed sleep patterns
  • Severe cardiac issues

 

 

In Case Of Abuse:

Physicians always warned patients to take medication keenly and even if unwillingly, the intake of Adderall 30 MG got abused it would result in boosted energy levels along with intense invigoration. Moreover, the abuse of latter drug may generate uncomforting symptoms like:

  • Less concentration over things
  • Depression and lethargy
  • Fatigue

Points To Keep In Mind:

Furthermore, before taking Adderall 30 MG there are few points to ponder.

Researchers suggested to people not to consume it if they have been using MAO inhibitor including linezoild, methylene blue injection, isocarboxazid, rasagiline and other in last 14 days as it may result in intense drugs interaction which is undoubtedly not healthy.

Additionally, a person with stimulant medicine allergies should avoid it or if she/he is already dealing with:

  • Any severe heart or coronary artery disease
  • Blood pressure (normal to high)
  • Intense anxiety and tension
  • Drug or alcohol addiction

What If A Person Is Dependent Of Adderall XR?

Dependence on such drug would have two kind of outcome i.e. Psychological and Physical.

A person would find him psychologically dependent or addict to it if he takes it on daily basis and it becomes part of his life. Plus, less access to it due to any reason could be disturbing and stress or headaches would occur frequently to psychologically addictive people.

Moreover, firstly, for psychologically dependent people consuming it often took to dangerous levels and they have to continue its intake even if means putting their life at risk. However, in such case, a cure is available. This habit can be improved by psychological treatment to change behavior patterns. A therapy called cognitive behavioral therapy could be helpful, according to experts.

Secondly, when person is used to availability of higher level dopamine in his brain and restricting Adderall XR in such case could drop dopamine’s level and person then faces:

 

  • Depression or tiredness
  • Sleeping abnormally or staying awake for unusual hours

It is pertinent to mention it here that this physical dependence may arouse urge to consume it more to stay satisfied which might lead a person towards several effects and over dose.

However, consuming them only after expert advice or measuring every possible precaution can prevent people from negative outcomes

AKB-48

Highlights:

AKB48 are a Japanese idol girl group formed in 2005. as of July 28, 2019 the group consists of 102 members, divided among several teams: Team A with 23 members, Team K with 23 members, Team B with 23 members, and Team 4 with 28 members, Team 8 with 38 members, the last of which have 33 members serving concurrently with other AKB48 teams. There are Kenkyusei members, 13 of whom serve on specific teams as understudies, and three of whom were recruited as a group of general understudies.[1]

Each of the teams has its own theme:[2] according to member Misaki Iwasa, Team A represents freedom, Team K has a strong and powerful image, Team B is very idol-like with cutesy costumes, and Team 4 represents “the future of AKB48”.[2] The member lineup often changes as when girls get older, they “graduate” from the group, and are replaced by members promoted from the trainees. Monica Hesse of The Washington Post describes the AKB48 audition process as “rolling American Idol-esque

Alprazolam

Highlights:

Alprazolam 0.5 MG Tablet is used to treat panic disorders and anxiety, like unexpected extreme fear and tension due to stress. It is recommended to start with a small dosage and increase it gradually. Do not stop taking this medicine suddenly as it may cause withdrawal symptoms like seizures, aggressive behavior, blurred vision, etc.

AMPHETAMINE POWDER

Highlights:

Amphetamine powder is a potent stimulator of the central nervous system (brain and nerves of the spinal cord) and has a medicinal role in a number of diseases. It is also highly addictive and has a history of abuse.

Amphetamine Powder is medically used to treat attention-deficit hyperactivity disorder

BROMADOL HCL

Highlights:

Bromadol HCL (BDPC) (efficient name 4-(4-bromophenyl)- 4-(dimethylamino)– 1-(2-phenylethyl)cyclohexanol; otherwise called bromadol) is a strong opiate pain relieving with an unmistakable arylcyclohexylamine substance structure. It was created by Daniel Lednicer at Upjohn in the 1970s

BUTYLONE

Highlights:

Butylone acts in a similar way as MDMA and Methylone, it causes an increase in extracellular monoamine levels
Butylone was first synthesized by Koeppe, Ludwig and Zeile which is mentioned in their 1967 paper

BUTYLONE CRYSTAL

Highlights:

Butylone Crystal can be synthesized in a laboratory via the following route: 3,4-methylenedioxybutyrophenone dissolved in dichloromethane to bromine gives 3′,4′-methylenedioxy-2-bromobutyrophenone. This product was then dissolved in

Buy 2C-I, 2C-E

Highlights:

Designer drugs like those of the 2C class have as much potential for abuse and adverse health effects, including overdose, as well-known intoxicants like cocaine

buy 4-Aco-DMT (10g) online

Highlights:

4-AcO-DMT (or psilacetin) is a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolized by the body into psilocin.

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